Prof Apryll Stalcup

Biography

Apryll Stalcup is Professor and Head of the School of Chemical Sciences at Dublin City University.  She received a BS in Chemistry from California State University-Sacramento (1979) and her PhD from Georgetown University in Washington, DC (1988).  She was a Co-op Fellow at the National Institute of Standards and Technology (NIST) in Gaithersburg, Maryland (1985-1988).  After a Postdoctoral Fellowship at the University of Missouri-Rolla, she moved to the University of Hawaii-Manoa in 1990.  In 1996, she moved to the University of Cincinnati and promoted to Full Professor in 2001.  She moved to Dublin City University In 2012 Dr. Stalcup’s research interests are in separation science.  Her group pioneered the use sulfated-β-cyclodextrin, heparin and quinine as chiral additives in capillary electrophoresis.  They have been very active in the application of surface-confined ionic liquids (SCIL) and demonstrated their wide application range (e.g., reversed phase, normal phase, ion exchange and ion exclusion).

In 2011, she was awarded the Cincinnati Chemist of the Year by the Cincinnati Section of the American Chemical Society.  In 2015, she received the American Microchemical Society A. A. Benedetti-Pichler Award.  Dr. Stalcup is the author of over 100 publications, reviews, book chapters and one patent.  She has served as the thesis/dissertation advisor or mentor to 32 postgraduate and Postdoctoral Fellows.  She is a Fellow of the Institute of Chemistry of Ireland, the Royal Society of Chemistry, a member of the American Chemical Society, the American Association of the Advancement of Science and Sigma Xi. She currently serves on the Royal Society of Chemistry Analytical Division Council, is a Contributing Editor for Trends in Analytical Chemistry and serves on the Editorial Board for Journal of Liquid Chromatography and Related Techniques. She is the Co-Chair (with Prof. Jeremy Glennon, University College Cork) of the 31st International Symposium on Chromatography in 2016.

Research Expertise

PhD Students

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Select Publications

Capillary electrophoretic application of 1-alkyl-3-methylimidazolium-based ionic liquids
  EG Yanes, SR Gratz, MJ Baldwin, SE Robison, AM Stalcup      2001      Analytical Chemistry
Ionic substances with melting points at or close to room temperature are referred to as ionic liquids. Interest in ionic liquids for their potential in different chemical processes is increasing, because they are environmentally benign and are good solvents for a wide range of both organic and inorganic materials. In this study, a capillary electrophoretic method for resolving phenolic compounds found in grape seed extracts is reported. The method, in which 1-alkyl-3-methylimidazolium-based ionic liquids are used as the running electrolytes, is simple and reproducible. The separation mechanism seems to involve association between the imidazolium cations and the polyphenols. The role of the alkyl substituents on the imidazolium cations was investigated and will be discussed.

 

Retention characteristics of a new butylimidazolium-based stationary phase
  Y Sun, B Cabovska, CE Evans, TH Ridgway, AM Stalcup      2005      Analytical and Bioanalytical Chemistry
A new HPLC stationary phase has been synthesized based on the ionic liquid n-butylimidazolium bromide. Imidazolium was covalently immobilized on a silica substrate through an n-alkyl tether and the retention characteristics of the resulting stationary phase were evaluated systematically. Using 28 small aromatic test solutes and reversed phase conditions, the linear solvation energy relationship approach was successfully used to characterize this new phase. The retention characteristics of the test solutes show remarkable similarity with phenyl stationary phases, despite the presence of a positive charge on the new imidazolium phase. Operated in the reversed phase mode, this new stationary phase shows considerable promise for the separation of neutral solutes and points to the potential for a truly multi-modal stationary phase.

 

Application of sulfated cyclodextrins to chiral separations by capillary zone electrophoresis
  AM Stalcup, KH Gahm      1996      Analytical Chemistry

Mixtures of randomly substituted sulfated cyclodextrins (degree of substitution, ∼7−10) were successfully used as chiral additives for the enantioseparation of 56 compounds of pharmaceutical interest, including anesthetics, antiarrhythmics, antidepressants, anticonvulsants, antihistamines, antihypertensives, antimalarials, relaxants, and bronchodilators. The separations were accomplished at pH 3.8, with the anode at the detector end of the column. Under these conditions, in which electroosmotic flow is directed toward the injection end of the column and the electrophoretic mobility of the negatively charged cyclodextrin is toward the detector, none of the analytes reached the detector in the absence of the sulfated cyclodextrin. Most (40) of the successfully resolved enantiomers contained basic functionality and a stereogenic carbon. However, the versatility of this sulfated cyclodextrin additive was also demonstrated by the fact that three atropisomers, 1,1‘-binaphthyl-2,2‘-diyl hydrogen phosphate, 1,1‘-binaphthyl-2,2‘-diol, and Troger’s base, and several neutral analytes were also successfully enantioresolved under these conditions. The separation mechanism seems to involve inclusion complexation.

 

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